Table II.
Reference Solubility Values (μg/mL) of the Studied Drugs at 24 h in Compendial and Biorelevant Media (mean ± SD, n = 3)
| Compendial media | Biorelevant media | |||
|---|---|---|---|---|
| Drug | 0.1 N HCl pH 1 | Phosphate buffer pH 6.8 | FaSSGF | FaSSIF-V2 |
| MTF | 3.1 × 105 (± 0.3 × 105) | 3.1 × 105 (± 0.2 × 105) | 3.4 × 105 (± 0.8 × 105) | 4.3 × 105 (± 0.4 × 105) |
| PRC | 1.6 × 104 (± 0.1 × 104) | 1.5 × 104 (± 0.1 × 104) | 1.7 × 104 (± 0.2 × 104) | 1.7 × 104 (± 0.1 × 104) |
| SMX | 1.6 × 103 (± 0.1 × 103) | 3.7 × 103 (± 0.1 × 103) | 862 (± 21) | 1.3 × 103 (± 0.1 × 103) |
| FRS | 14 (± 2) | 3.4 × 103 (± 1.4 × 102) | 15 (± 1) | 1.6 × 103 (± 3.0 × 102) |
| CBZ | 265 (± 6) | 227 (± 9) | 368 (± 1) | 280 (± 7) |
| DPL | 1.3 × 104 (± 9.1 × 102) | 5 (± 1) | 8.6 × 103 (± 2.0 × 102) | 13 (± 1) |
| IBU | 43 (± 3) | 5.5 × 103 (± 6.7 × 102) | 44 (± 5) | 1.5 × 103 (± 5.8) |
| ITZ | 11 (± 1) | –a | 1.2 (± 0.2) | 0.05 (± 0.01) |
aBelow limit of detection of the analytical method
MTF metformin, PRC paracetamol, SMX sulfamethoxazole, FRS furosemide, CBZ carbamazepine, DPL dipyridamole, IBU ibuprofen, ITZ itraconazole