Table 2.
Articles describing the formation of heterotopic ossification in non-FOP patients as a late effect of radiotherapy.
| References | Design | Number of patients | Reason RT | Dosage | Time interval RT and HO (years) | |
|---|---|---|---|---|---|---|
| 1 | Carl and Hartmann (16) | Case series | 15 | Various carcinomas | BED 67–214 Gya | 19 (range 2–31) |
| 2 | Kruse et al. (17) | Case report | 1 | Nasopharyngeal carcinoma | Unknown | 3b |
| 3 | Park et al. (18) | Case report | 1 | Tonsil cancer | Unknown | 14 |
| 4 | Portha et al. (19) | Case report | 1 | Metastasized mamma carcinoma | Unknown | 1 |
| 5 | Harmon and Nielsen (20) | Case report | 1 | Testicular tumor | Unknown | 33 |
a
Various kinds of radiotherapy given, potential for overlap could lead to underestimate of radiation dose.
b
Additional factors: chemotherapy, intubation on intensive care, immobilization, critical illness neuromyopathy.
BED, biological effective dose (with α/β = 3 for late tissue effects).