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. 2020 Feb 18;70:12. doi: 10.1186/s12576-020-00741-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 12 — Simulation of quick releases of the virtual sample during the isometric cycle in the TP + M model. The initial length L_init is equal to 90%L_max. The sample is quickly released to 95%L_init at 90 and 240 ms after the stimulus and is held at a new length until the end of the cycle. a–d Virtual sample length, force development, intracellular Ca²⁺ transient ([Ca²⁺]_i) and membrane potential in the simulation