Table 2.
Association between first‐trimester blood urea nitrogen and the development of gestational diabetes mellitus
| N (%) | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | P‐value | OR (95% CI) | P‐value | OR (95% CI) | P‐value | ||
| Quartiles | |||||||
| Q1 (<2.40) | 591 (18.42) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | |||
| Q2 (2.40‐2.91) | 678 (19.32) | 1.06 (0.94‐1.20) | .344 | 1.02 (0.90‐1.15) | .807 | 1.01 (0.89‐1.15) | .825 |
| Q3 (2.91‐3.50) | 745 (23.10) | 1.33 (1.18‐1.50) | <.001 | 1.22 (1.08‐1.38) | .002 | 1.21 (1.07‐1.37) | .002 |
| Q4 (≥3.50) | 959 (27.36) | 1.67 (1.49‐1.87) | <.001 | 1.50 (1.33‐1.69) | <.001 | 1.50 (1.33‐1.69) | <.001 |
| P‐value for trend | <.001 | <.001 | <.001 | ||||
| Cut‐off of ROC curve | |||||||
| <3.15 | 1571 (19.30) | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | |||
| ≥3.15 | 1402 (26.40) | 1.50 (1.38‐1.63) | <.001 | 1.39 (1.28‐1.51) | <.001 | 1.39 (1.28‐1.51) | <.001 |
| Per log‐SD increment | 1.12 (1.08‐1.16) | <.001 | 1.08 (1.04‐1.12) | <.001 | 1.08 (1.04‐1.13) | <.001 | |
Model 1 was unadjusted. Model 2 adjusted for maternal age, education, gravidity, parity, baseline BMI, gestational weight gain, systolic BP, FPG, WBC and haemoglobin. Model 3 adjusted the factors in model 2 and eGFR.