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. 2020 Jan 13;24(4):2497–2506. doi: 10.1111/jcmm.14941

Figure 3.

Figure 3

α5‐nAChR expression mediates Stat3, Jab1, N‐cadherin and Vimentin expression in vitro. A, Expression of α5‐nAChR and Jab1 in six NSCLC cell lines (95D, H1299, H1975, A549, H1650 and H226) and the normal epithelial lung cell line (BEAS‐2B). B, The expression of α5‐nAChR and Jab1 was increased by nicotine stimulation in A549 and H1299 cells. C, α5‐nAChR silencing down‐regulated p‐Stat3, Jab1, N‐cadherin and Vimentin in A549 cells and H1299 cells. **P < .01, *P < .05, si‐NC vs si‐CHRNA5. D, Overexpression of α5‐nAChR up‐regulated p‐Stat3, Jab1, N‐cadherin and Vimentin levels in A549 cells and H1299 cells. **P < .01, *P < .05, Ctrl vs α5‐nAChR+