Figure 3.

VEGF‐A production by human PA‐TU‐8902 pancreatic cancer cells exposed to Arthrospira platensis and various anti‐angiogenic drugs: (A) VEGF‐A mRNA expression after 1‐ and 24‐h exposure to A platensis extract. B, VEGF‐A protein production upon 24‐h exposure to A platensis extract. C, VEGF‐A protein production upon 5‐h exposure to various anti‐angiogenic drugs. The VEGF‐A mRNA level was determined by RT‐qPCR. The concentrations of VEGF‐A secreted into the medium of PA‐TU‐8902 cells were detected by ELISA. The following concentrations of anti‐angiogenic factors were used: A platensis extract (0.3 g/L), PCB (125 μmol/L), axitinib (50 nmol/L) and vatalanib (1 μmol/L). Data expressed as % of control values and represent median ± IQ range. ^p P = .054 vs control; *P < .05 vs control; **P < .01 vs control. A pl., A platensis; PCB, phycocyanobilin