Table 2.
The functional categories of 400 DUPs identified with GO analysis
| Category | Term | p value |
|---|---|---|
| Annotation cluster 1 | ||
| GOTERM_MF_DIRECT | Cadherin binding involved in cell–cell adhesion | 3.11E-18 |
| GOTERM_CC_DIRECT | Cell–cell adherens junction | 2.24E-17 |
| GOTERM_BP_DIRECT | Cell–cell adhesion | 1.23E-13 |
| Annotation cluster 2 | ||
| GOTERM_CC_DIRECT | Proteasome accessory complex | 4.60E-12 |
| GOTERM_BP_DIRECT | Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 1.59E-11 |
| GOTERM_BP_DIRECT | Regulation of cellular amino acid metabolic process | 3.49E-09 |
| GOTERM_BP_DIRECT | NIK/NF-kappaB signaling | 5.35E-09 |
| GOTERM_BP_DIRECT | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.27E-08 |
| GOTERM_BP_DIRECT | Stimulatory C-type lectin receptor signaling pathway | 1.85E-08 |
| GOTERM_BP_DIRECT | Positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition | 2.83E-08 |
| GOTERM_BP_DIRECT | Anaphase-promoting complex-dependent catabolic process | 4.43E-08 |
| GOTERM_BP_DIRECT | Tumor necrosis factor-mediated signaling pathway | 8.37E-08 |
| GOTERM_BP_DIRECT | Positive regulation of canonical Wnt signaling pathway | 1.04E-07 |
| GOTERM_BP_DIRECT | T cell receptor signaling pathway | 2.37E-07 |
| GOTERM_BP_DIRECT | Fc-epsilon receptor signaling pathway | 4.90E-07 |
| GOTERM_BP_DIRECT | Protein polyubiquitination | 7.65E-07 |
| GOTERM_BP_DIRECT | Negative regulation of canonical Wnt signaling pathway | 4.36E-06 |
| Annotation cluster 3 | ||
| GOTERM_CC_DIRECT | Proteasome regulatory particle, base subcomplex | 4.88E-10 |
| GOTERM_CC_DIRECT | Nuclear proteasome complex | 1.00E-09 |
| GOTERM_CC_DIRECT | Cytosolic proteasome complex | 7.28E-09 |
| GOTERM_MF_DIRECT | Proteasome-activating ATPase activity | 1.54E-08 |
| GOTERM_BP_DIRECT | Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly | 3.41E-07 |
| GOTERM_MF_DIRECT | TBP-class protein binding | 2.10E-06 |
| GOTERM_BP_DIRECT | Positive regulation of proteasomal protein catabolic process | 1.05E-05 |
| GOTERM_BP_DIRECT | Protein catabolic process | 1.41E-04 |
| Annotation cluster 4 | ||
| GOTERM_BP_DIRECT | Regulation of ventricular cardiac muscle cell action potential | 1.11E-03 |
| GOTERM_MF_DIRECT | Cell-adhesive protein binding involved in bundle of His cell–Purkinje myocyte communication | 5.30E-03 |
| Annotation cluster 5 | ||
| GOTERM_CC_DIRECT | Haptoglobin–hemoglobin complex | 2.43E-05 |
| GOTERM_CC_DIRECT | Endocytic vesicle lumen | 1.71E-04 |
| GOTERM_MF_DIRECT | Haptoglobin binding | 1.10E-03 |
| GOTERM_BP_DIRECT | Positive regulation of cell death | 1.90E-02 |
| GOTERM_CC_DIRECT | Hemoglobin complex | 1.97E-02 |
| GOTERM_MF_DIRECT | Oxygen transporter activity | 2.90E-02 |
| GOTERM_BP_DIRECT | Oxygen transport | 3.43E-02 |
| Annotation cluster 6 | ||
| GOTERM_BP_DIRECT | SRP-dependent cotranslational protein targeting to membrane | 9.85E-05 |
| GOTERM_BP_DIRECT | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 5.83E-04 |
| GOTERM_BP_DIRECT | Viral transcription | 1.69E-03 |
| GOTERM_BP_DIRECT | Translational initiation | 5.82E-03 |
| GOTERM_CC_DIRECT | Ribosome | 3.40E-02 |
| Annotation cluster 7 | ||
| GOTERM_MF_DIRECT | Voltage-gated anion channel activity | 5.30E-03 |
| GOTERM_MF_DIRECT | Porin activity | 5.30E-03 |
| GOTERM_CC_DIRECT | Pore complex | 1.11E-02 |
| GOTERM_BP_DIRECT | Anion transport | 3.02E-02 |
| GOTERM_BP_DIRECT | Regulation of anion transmembrane transport | 4.34E-02 |
| Annotation cluster 8 | ||
| GOTERM_BP_DIRECT | Daunorubicin metabolic process | 1.00E-02 |
| GOTERM_BP_DIRECT | Doxorubicin metabolic process | 1.00E-02 |
| Annotation cluster 9 | ||
| GOTERM_BP_DIRECT | Nucleotide-excision repair, DNA damage recognition | 1.00E-02 |
| GOTERM_BP_DIRECT | Global genome nucleotide-excision repair | 2.47E-02 |
| Annotation cluster 10 | ||
| GOTERM_MF_DIRECT | Neutral amino acid transmembrane transporter activity | 1.82E-02 |
| GOTERM_BP_DIRECT | Neutral amino acid transport | 2.62E-02 |