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. 2020 Feb 18;10:2815. doi: 10.1038/s41598-020-59736-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TF-CAR-NK cell therapy was effective and safe for the treatment of human TNBC PDX in an orthotopic NSG mouse model. TNBC PDX (JAX) was generated in four-week old female NSG mice, as described above and in our published study¹⁴. When the PDX tumors reached ~100 mm³, NK-CAR1 dimer (NK92MI/fCD16/CAR1 dimer) or NK92MI/fCD16 cells without CAR constructs (as a control) were injected i.v. via tail veins two times (3 × 10⁶ cells per mouse on day 0 and 2 × 10⁶ cells per mouse on day 17, arrows) (five mice per group). (A) Tumor volumes. (B,C) Tumor weights and mouse body weights were measured at the time of sacrifice of animals. ns: no significance; *, **, ***, ****p < 0.05, 0.01, 0.001 and 0.0001.