Table 1.

Overview of the included studies

First author	Ref.	Origin of cohort	Germline (G) or clinical definition (C)	N (LS patients)	N (Polyps)	Technique PCR (M) or IHC (I)
Ahadova	50	Germanya	G	15	21	I
Akiyama	29	Japan	C	10	14	M
Aldecoa	13	Spain	G	53	171	I
Chang	51	USA and Italy	G	9	9	I
De Jong	8	Netherlands	G	22	31	I
Ferreira	30	Portugal	C or G	16	16	M
Giuffre	31	Germany	C	17	18	M and I
Halvarsson	32	Sweden	G	26	35	M and I
Iino	33	Australia	C or G	24	47	M and I
Loukola	34	Finland	C or G	12	12	M
Meijer	25	Netherlands	G	38	50	I
Muller	35	Germany	C or G	36	71	M and I
Pedroni	36	Italy	C or G	7	12	M and I
Pino	37	USA	G	15	44	M and I
Porkka	23	Finland	G	Unknown	11	M
Rijcken	56	Netherlands	C or G	40	90	I
Rijcken	20	Netherlands	C or G	Unknown	25	I
Shia	21	USA	C or Gc	Unknown	29	M and I
Tanaka	18	Japan	G	26	134	I
Valo	22	Finland	G	Unknown	47	M and I
van Lier	38	Netherlands	G	3	3	M and I
Velayos	39	USA	G	3b	4	M and I
Walsh	40	Australia	G	69	109	M and I
Walsh	41	Australia	C or G	7	22	M and I
Young	42	Australia	C or G	18	25	M
Yurgelun	43	USA	G	34	62	M and I

First author	Ref.	Origin of cohort	Germline (G) or clinical definition (C)	N (Unselected patients)	N (Polyps)	Technique PCR (M) or IHC (I)
Basterra	44	Spain	No	187	187	I
Ferreira	30	Portugal	No	23	27	M
Goverde	54	Netherlands	No	400	400	I
Koh	45	USA	No	23b	38	M and I
Kushnir	46	USA	No	66	66	I
Loukola	34	Finland	No	367	390	M
Meijer	25	Netherlands	No	Unknown	19	I
Mendelsohn	7	USA	No	208	259	I
Patil	26	USA	No	Unknown	127	M and I
Pedroni	36	Italy	No	3	6	M and I
Reveron	27	USA	No	Unknown	27	I
Ricciardiello	47	Italy	No	70	70	M and I
Samowitz	9	USA	No	48	93	M
Samowitz	24	USA	No	Unknown	71	M
Sekine	17	Japan	No	25	84	M and I
Sheridan	53	USA	No	6	6	I
Strul	48	Israel	No	40	40	M
Ueda	49	Japan	No	76	76	M
van Lier	38	Netherlands	No	122	122	M and I
Velayos	39	USA	No	34b	40	M and I
Yamane	28	Brazil	No	103	103	M

^aUnclear

^bOnly patients under the age of 40 years are included

^cIncluding Lynch like patients