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Effect of DUSP4 depletion on response to MEK inhibition in BRAF wild-type melanoma cells.
| Cell line | CHL-1 | SK-MEL-23 | ||
|---|---|---|---|---|
| MEK inhibitor | Selumetinib | Trametinib | Selumetinib | Trametinib |
| Fold increase in SF50 | 6.71 ± 1.30 | 6.85 ± 2.42 | 2.94 ± 0.40 | 2.48 ± 0.44 |
| p-value | 0.0072 | 0.0605 | 0.0048 | 0.02 |
The table shows mean ± SEM fold increase in SF50 values in DUSP4-depleted CHL-1 and SK-MEL-23 cells (n = 6 in each case; data analysed using two-tailed t test).
