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. 2020 Feb 18;11(2):131. doi: 10.1038/s41419-020-2326-2

Fig. 3. BP-1-102 inhibited inflammatory cells infiltration and suppressed pro-inflammatory cytokines expression.

Fig. 3

a The part of aorta with maximum diameter aorta was collected and embedded. Five-micrometer sections were made for HE staining. Representative histology images of AAA at indicated time points were shown. The integrity of aortic wall in AngII+ BP-1-102+ group (AngII+BP+), were maintained comparing with that of AngII+ group, while the inflammatory cells infiltrations were reduced in AngII+ BP-1-102+ group comparing with that of AngII+ group. b Inflammation-related cytokines expression in AAA tissues were determined using proteome profiler Mouse cytokine Array kit. Densitometry volume of each cytokine was determined and statistically analyzed. CXCL-10, IL-1β, IL-1Rα, IL-6, MCP-1, MIP-1α, and RANTES were all decreased in AngII+ BP-1-102+ group (AngII+BP+, blue column) compared with AngII+ group (red column) at each time point. While the anti-inflammation factor IL-10 was significantly increased in AngII+ BP-1-102+ group (AngII+BP+), compared with the AngII+ group. Saline treated group were used as control (green column). The results were presented as mean ± standard deviation (SD). n= 8. *P < 0.01 vs. AngII+ group (two-way ANOVA followed by Tukey’s test). NS indicates non-significant differences compared with AngII+ group.