Table 1.
Demographic and clinical characteristics of healthy controls and HBV patients.
| Characteristics | HC (n = 297) | HBV patients (n = 756) | CHB (n = 246) | LC (n = 174) | HCC (n = 336) | P value |
|---|---|---|---|---|---|---|
| Age (years) | 43 [16–69] | 52 [12–91] | 41 [12–85] | 56 [20–86] | 57 [15–91] | <0.0001# |
| Male (%) | 66.7 | 83.3 | 75.2 | 82.8 | 93.7 | <0.0001β |
| Child-Pugh | NA | |||||
| Child A | NA | 53/169 | 249/335 | |||
| Child B | NA | 75/169 | 65/300 | |||
| Child C | NA | 41/169 | 21/335 | |||
| Missing | NA | 5 | 1 | |||
| Clinical parameters | ||||||
| AST (IU/L) | NR | 132 [14–6206] | 187 [14–6206] | 119 [15–1221] | 101 [17–983] | <0.0001# |
| ALT (IU/L) | NR | 132 [8–3390] | 222 [9–3390] | 82 [8–1426] | 72 [11–1095] | 0.04# |
| Total bilirubin (µmol/L) | NR | 39.1 [4.1–571] | 34 [5.5–551] | 65.2 [4.1–571] | 29.4 [4.3–392] | <0.0001# |
| Direct bilirubin (µmol/L) | NR | 17.2 [0.4–349] | 16.1 [0.7–349] | 29.5 [0.4–291] | 11.6 [0.4–247.3] | <0.0001# |
| Albumin (g/L) | NR | 37 [15–48] | 42 [25–48] | 31.8 [15–47] | 37 [15–48] | <0.0001# |
| Prothrombin (% of standard) | NR | 82 [13–269] | 94 [17–267] | 60 [13–101] | 84 [20–269] | <0.0001# |
| <0.0001# | ||||||
| WBC (×103/mL) | NR | 6.6 [1.7–20.5] | 6.7 [4.1–13.44] | 6.2 [1.7–20.5] | 6.8 [2.7–17.9] | <0.0001# |
| RBC(×106/mL) | NR | 4.5 [1.7–6.8] | 4.9 [3.1–6.8] | 3.9 [1.9–6.7] | 4.5 [1.7–6.8] | <0.0001# |
| PLT (×103/ml) | NR | 174 [17–441] | 218 [66–379] | 106 [17–441] | 177 [34–432] | <0.0001# |
| HBV DNA (log10 copies/ml) | NR | 5.1 [1–10] | 5.2 [2–10] | 5 [1–10] | 5.1 [1–9] | 0.4# |
| AFP (IU/L) | NR | 142 [1–4029] | 7.4 [1–250] | 40 [1.18–707] | 280 [1–4029] | <0.0001# |
CHB, chronic hepatitis B; LC, liver cirrhosis; HCC, hepatocellular carcinoma; HC, healthy control; RBC, red blood cells; WBC, white blood cells; PLT, platelets. AST and ALT, aspartate and alanine aminotransferase; AFP, alpha-fetoprotein; NR, normal range, NA, not applicable. Values given are medians and ranges. (#) Kruskal-Wallis test (β): chi-square test.