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. 2020 Feb 18;11:855. doi: 10.1038/s41467-020-14676-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative images of ultrastructure of synapse. b, c The length and width of PSD (n = 6 slices per group). d, e Western blots analysis of hippocampal IRS/Akt and CREB/ERK related signaling (n = 3 mice per group). Data presented as mean ± SEM. *p < 0.05, **p < 0.01, compared with db/m group, ^#p < 0.05, ^##p < 0.01 compared with the db/db group. Significant differences between mean values were determined by one-way ANOVA with Tukey’s multiple comparisons test. See also Supplementary Fig. 2. Source data are provided as a Source Data file.