Table 1.
List of microbiomes significantly changed in CRC.
| Phylum | Genus | MAV of healthy controls (%) | MAV of CRC patients (%) | Log2 | p-value | FDR adjusted p-value | Regulation |
|---|---|---|---|---|---|---|---|
| (Fold change) | (Wilcoxon) | (Wilcoxon) | |||||
| Actinobacteria | Actinomyces | 0.646 | 0.053 | −3.613 | 0.000 | 0.001 | Down |
| Bifidobacterium | 0.871 | 1.832 | 1.073 | 0.001 | 0.014 | Up | |
| Rothia | 0.533 | 0.016 | −5.099 | 0.000 | 0.000 | Down | |
| Propionibacterium | 0.685 | 0.164 | −2.061 | 0.000 | 0.000 | Down | |
| Collinsella | 0.065 | 0.953 | 3.880 | 0.000 | 0.000 | Up | |
| Bacteroidetes | Bacteroidales S24-7 group (f) | 0.610 | 0.491 | −0.313 | 0.003 | 0.031 | Down |
| Cyanobacteria | Chloroplast (o) | 0.507 | 0.059 | −3.104 | 0.000 | 0.000 | Down |
| Firmicutes | Blautia | 0.187 | 0.599 | 1.677 | 0.000 | 0.000 | Up |
| Lachnoclostridium | 0.096 | 0.740 | 2.943 | 0.000 | 0.000 | Up | |
| Lachnospiraceae NK4A136 group | 0.561 | 0.170 | −1.718 | 0.002 | 0.019 | Down | |
| Lachnospiraceae UCG-008 | 0.591 | 1.069 | 0.855 | 0.000 | 0.000 | Up | |
| Dorea | 0.450 | 0.510 | 0.181 | 0.000 | 0.008 | Up | |
| [Eubacterium] coprostanoligenes group | 1.332 | 5.696 | 2.096 | 0.000 | 0.000 | Up | |
| Ruminococcaceae UCG-002 | 0.484 | 2.180 | 2.171 | 0.000 | 0.002 | Up | |
| Ruminococcus 2 | 0.530 | 2.329 | 2.136 | 0.000 | 0.002 | Up | |
| Subdoligranulum | 0.562 | 2.408 | 2.099 | 0.000 | 0.000 | Up | |
| Ruminococcaceae (f) | 0.317 | 1.187 | 1.905 | 0.000 | 0.000 | Up | |
| Ruminococcaceae UCG-014 | 1.098 | 0.706 | −0.638 | 0.000 | 0.004 | Down | |
| Faecalibacterium | 4.624 | 11.974 | 1.373 | 0.000 | 0.003 | Up | |
| Ruminococcaceae NK4A214 group | 0.209 | 1.045 | 2.319 | 0.001 | 0.009 | Up | |
| Staphylococcus | 0.819 | 0.410 | −0.998 | 0.003 | 0.033 | Down | |
| Catenibacterium | 0.041 | 0.729 | 4.161 | 0.000 | 0.000 | Up | |
| Parvimonas | 0.028 | 0.812 | 4.840 | 0.001 | 0.013 | Up | |
| Ruminiclostridium 5 | 0.083 | 0.527 | 2.672 | 0.001 | 0.010 | Up | |
| Proteobacteria | Methylobacterium | 2.846 | 0.027 | −6.743 | 0.000 | 0.007 | Down |
| Solanum melongena (eggplant) | 1.046 | 0.141 | −2.887 | 0.000 | 0.000 | Down | |
| Sphingomonas | 0.548 | 0.172 | −1.674 | 0.000 | 0.000 | Down | |
| Diaphorobacter | 0.000 | 0.974 | 12.397 | 0.000 | 0.001 | Up | |
| Escherichia-Shigella | 3.427 | 0.871 | −1.975 | 0.000 | 0.000 | Down | |
| Proteus | 1.169 | 0.000 | « | 0.000 | 0.000 | Down | |
| Pseudomonas | 2.913 | 0.242 | −3.589 | 0.000 | 0.000 | Down | |
| Enterobacter | 0.158 | 0.816 | 2.370 | 0.004 | 0.035 | Up | |
| Saccharibacteria | Saccaribacteria (p) | 0.540 | 0.132 | −2.029 | 0.001 | 0.017 | Down |
| Tenericutes | Mollicutes RF9 (o) | 2.053 | 0.208 | −3.304 | 0.001 | 0.011 | Down |
MAV indicates mean abuandance value; Fold-change indicates the difference in the mean abundance values between CRC patients and healthy controls; for comparison of the relative abundance of the two groups, false discovery rate-adjusted p-values were calculated.