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Flow-chart of the study methodology. HC: healthy controls; IBS: diarrhea predominant irritable bowel syndrome patients; DD: depressive disorder patients; WES: whole-exome sequencing; SNV: single nucleotide variations; InDel: insertion or deletion; SIFT: sorting intolerant from tolerant; LRT: likelihood ratio test; pcmh: significance in comparison of the patient group with healthy controls, Cochran–Mantel–Haenszel test.
