Table 2.
Working heart function during glucosamine perfusions
Values include both unlabeled and 13C-labeled glucosamine perfusions. Cardiac function is reported at 20-min perfusion time (both 30- and 60-min perfusion duration groups) and at 50-min perfusion time (60-min perfusions only). Values are mean ± S.E. *, p < 0.05 versus 20-min glucosamine (0.001 mm). #, p < 0.05 versus 20-min glucosamine (0.01 mm).
| Glucosamine (mm) | 20 min |
45 min |
||||
|---|---|---|---|---|---|---|
| 0.001 (n = 12) | 0.01 (n = 12) | 0.05 (n = 6) | 0.1 (n = 10) | 0.001 (n = 5) | 0.01 (n = 6) | |
| Heart rate (beats/min) | 372 ± 8 | 383 ± 10 | 406 ± 15 | 400 ± 17 | 392 ± 20 | 381 ± 16 |
| Developed pressure (mm Hg) | 71.5 ± 1.9 | 70.3 ± 2.4 | 67.7 ± 2.4 | 67.6 ± 2.1 | 72.4 ± 2.8 | 69.0 ± 1.4 |
| +dP/dTmax (mm Hg/s) | 4346 ± 147 | 4170 ± 180 | 3744 ± 184* | 3650 ± 150*# | 4435 ± 185 | 4092 ± 125 |
| −dP/dTmin (mm Hg/s) | −3269 ± 112 | −3183 ± 117 | −3269 ± 227 | −3144 ± 123 | −3129 ± 77 | −3053 ± 166 |
| Aortic flow (ml/min) | 11.2 ± 0.4 | 10.7 ± 0.5 | 9.9 ± 0.6 | 11.0 ± 0.3 | 10.6 ± 0.3 | 8.5 ± 1.1 |
| Coronary flow (ml/min) | 3.1 ± 0.2 | 3.3 ± 0.3 | 3.4 ± 0.2 | 3.1 ± 0.2 | 3.0 ± 0.2 | 4.1 ± 0.4 |
| MVO2 (μmol/g wet weight/min) | 6.1 ± 0.3 | 6.7 ± 0.7 | 6.7 ± 0.4 | 6.7 ± 0.5 | 5.8 ± 0.1 | 7.6 ± 0.7 |