Table 3.
Working heart function for the [U-13C6]glucose perfusions
Reported values are just prior to the end of the perfusion. Values are mean ± S.E. *, p < 0.05 versus [U-13C6]glucose 5.5 mm for the same perfusion duration.
| Perfusion duration (min) | 5.5 mm [U-13C6]glucose |
25 mm [U-13C6]glucose |
||||||
|---|---|---|---|---|---|---|---|---|
| 10 (n = 5) | 20 (n = 3) | 30 (n = 3) | 60 (n = 2) | 10 (n = 4) | 20 (n = 5) | 30 (n = 3) | 60 (n = 2) | |
| Heart rate (beats/min) | 368 ± 27 | 374 ± 19 | 351 ± 32 | 409 ± 11 | 378 ± 23 | 332 ± 16 | 332 ± 8 | 344 ± 14 |
| Developed pressure (mm Hg) | 63.2 ± 2.8 | 60.7 ± 2.2 | 60.0 ± 1.5 | 66.5 ± 3.5 | 67.5 ± 5.1 | 66.8 ± 2.4 | 70.7 ± 3.7 | 64.0 ± 5.0 |
| +dP/dTmax (mm Hg/s) | 3570 ± 300 | 3286 ± 265 | 3744 ± 184 | 3117 ± 178 | 3647 ± 138 | 4023 ± 168* | 4526 ± 361* | 3720 ± 199 |
| −dP/dTmin (mm Hg/s) | −3161 ± 368 | −2721 ± 98 | −2720 ± 589 | −2631 ± 317 | −2890 ± 177 | −2915 ± 96 | −3053 ± 109 | −3160 ± 303 |
| Aortic flow (ml/min) | 8.2 ± 0.8 | 9.3 ± 0.2 | 9.1 ± 0.5 | 6.4 ± 2.0 | 10.5 ± 0.9 | 10.2 ± 0.4 | 10.1 ± 0.2 | 10.2 ± 0.3 |
| Coronary flow (ml/min) | 3.9 ± 1.1 | 2.6 ± 0.3 | 2.8 ± 0.5 | 2.2 ± 0.4 | 5.3 ± 1.8 | 2.8 ± 0.2 | 3.5 ± 0.4 | 2.7 ± 0.1 |
| MVO2 (μmol/g wet weight/min) | 10.8 ± 3.3 | 6.7 ± 0.5 | 7.0 ± 0.3 | 6.2 ± 0.8 | 9.1 ± 0.6 | 8.1 ± 0.4 | 8.6 ± 0.4 | 6.7 ± 0.9 |