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. 2020 Jan 8;295(7):2068–2083. doi: 10.1074/jbc.RA119.011775

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© 2020 Durand et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 13. — Schematic representation of PC7 trafficking and cleavage activity. The table summarizes the cleavage activity and trafficking of hPC7 and its mutants to the TGN (Golgin-97), cell surface, and early endosomes (EEA1). Activity cleavage results are semi-quantitative and normalized to the WT hPC7 (100%). The cartoon summarizes the localization and cleavage activity of PC7 WT (green CT) and its EXEXXXL mutant (red CT) and the regulation of hPC7 in the presence of AP-2 (blue). CCV, clathrin-coated vesicles; nd, not determined.