Figure 5.

Cartoon representation of solution NMR structure of the human PC7 14-mer CT peptide (aa 717–730) and its Ala mutant. A, ensemble of 10 water-refined structures of CT peptide (aa 717–730). The side chains of Glu-719, Glu-721, and Leu-725 are displayed as lines with C atoms in blue and O atoms in red. B, ensemble of 10 water-refined structures of Ala-719,721,725–mutated CT peptide (aa 717–730). The side chain of mutated residues are shown as green lines. C, alignment of average energy minimized structures of both peptides with the same color code.