Table 2.
Identification of proteins shed into circulation after TBI that elicited the formation of autoantibodies in the serum of TBI-mice and identified with PELS.
| Identified proteins | Accession number | Molecular weight | Number of unique peptides | UniProtKB | Gene symbol |
|---|---|---|---|---|---|
| Fructose-bisphosphate aldolase A | IPI00221402 | 39 kDa | 11 | P05064 | ALDOA |
| 40S ribosomal protein S19 | IPI00113241 (+5) | 16 kDa | 7 | Q9CZX8 | Rps19 |
| Alpha globin 1 | IPI00845802 | 15 kDa | 7 | Q91VB8 | Hba-a1 |
| 40S ribosomal protein S13 | IPI00125901 (+2) | 17 kDa | 6 | P62301 | Rps13 |
| 60S ribosomal protein L27 | IPI00122421 (+1) | 16 kDa | 6 | P61358 | Rpl27 |
| Histone H2B type 1-F/J/L | IPI00114642 (+10) | 14 kDa | 5 | P10853 | Hist1h2bf |
| Hemoglobin subunit beta-1 | IPI00762198 (+3) | 16 kDa | 5 | P02088 | Hbb-b1 |
| 40S ribosomal protein S15 | IPI00319231 (+1) | 17 kDa | 4 | P62843 | Rps15 |
| Isoform 2 of 40S ribosomal protein S24 | IPI00402981 (+4) | 15 kDa | 4 | P62849 | Rps24 |
| 60S ribosomal protein L29 | IPI00222548 (+9) | 18 kDa | 3 | P47915 | Rpl29 |
| Histone H1.4 | IPI00223714 | 22 kDa | 3 | P43274 | Hist1h1e |
| 60S ribosomal protein L13 | IPI00224505 (+1) | 24 kDa | 3 | P47963 | Rpl13 |
| 60S ribosomal protein L6 | IPI00313222 (+2) | 34 kDa | 3 | P47911 | Rpl6 |
| 40S ribosomal protein S10 | IPI00112448 | 19 kDa | 3 | P63325 | Rps10 |
| 40S ribosomal protein S18 | IPI00317590 (+2) | 18 kDa | 3 | P62270 | Rps18 |
| 60S ribosomal protein L39 | IPI00273974 (+4) | 6 kDa | 2 | P62892 | Rpl39 |
| Isoform 1 of GRB10-interacting GYF protein 2 | IPI00473912 (+1) | 149 kDa | 2 | Q6Y7W8 | Gigyf2 |
| 40S ribosomal protein S7 | IPI00136984 (+1) | 22 kDa | 2 | P62082 | Rps7 |
| 40S ribosomal protein S29 | IPI00222553 | 7 kDa | 2 | P62274 | Rps29 |
| 60S ribosomal protein L35a | IPI00115902 (+1) | 13 kDa | 2 | O55142 | Rpl35a |
| Histone H2A.J | IPI00153400 (+13) | 14 kDa | 2 | Q8R1M2 | H2afj |
| Isoform Ib of Synapsin-1 | IPI00136372 (+1) | 70 kDa | 2 | O88935 | Syn1 |
| Isoform 2 of Heterogeneous nuclear ribonucleoprotein Q | IPI00406118 (+3) | 63 kDa | 1 | Q7TMK9 | Syncrip |
| Isoform 2 of Calcium-activated potassium channel subunit alpha-1 | IPI00120643 (+12) | 135 kDa | 1 | Q08460 | Kcnma1 |
| 60S ribosomal protein L18 | IPI00555113 (+1) | 22 kDa | 1 | P35980 | Rpl18 |
| CCAAT/enhancer-binding protein beta | IPI00116613 (+3) | 31 kDa | 1 | P28033 | Cebpb |
| 60S ribosomal protein L8 | IPI00137787 | 28 kDa | 1 | P62918 | Rpl8 |
| 60S ribosomal protein L35 | IPI00263879 (+1) | 15 kDa | 1 | Q6ZWV7 | Rpl35 |
| Histone H1.3 | IPI00331597 | 22 kDa | 1 | P43277 | Hist1h1d |
| Anti-colorectal carcinoma light chain | IPI00462809 (+7) | 26 kDa | 1 | Q7TS98 | N/A |
| Isoform 1 of Protein FAM126B | IPI00226426 (+1) | 59 kDa | 1 | Q8C729 | Fam126b |
| V-type proton ATPase subunit G 2 | IPI00123817 (+1) | 14 kDa | 1 | Q9WTT4 | Atp6v1g2 |
| Plexin-A2 | IPI00137313 | 212 kDa | 1 | P70207 | Plxna2 |
| Nuclear receptor subfamily 1 group D member 2 | IPI00119178 | 64 kDa | 1 | Q60674 | Nr1d2 |
| Serine/arginine-rich splicing factor 2 | IPI00121135 (+2) | 25 kDa | 1 | Q62093 | Sfrs2 |
| Keratin, type II cytoskeletal 6B | IPI00131366 (+7) | 60 kDa | 1 | Q9Z331 | Krt6b |
| Isoform 1 of Dynamin-1 | IPI00272878 (+5) | 98 kDa | 1 | P39053 | Dnm1 |
| 60S ribosomal protein L24 | IPI00323806 (+3) | 18 kDa | 1 | Q8BP67 | Rpl24 |
| Isoform 1 of Syntaxin-binding protein 1 | IPI00415402 (+2) | 68 kDa | 1 | O08599 | Stxbp1 |
| Peptidyl-prolyl cis-trans isomerase A | IPI00554989 | 18 kDa | 1 | P17742 | Ppia |
| Probable G-protein coupled receptor 158 | IPI00465871 | 134 kDa | 1 | Q8C419 | Gpr158 |
| Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial | IPI00406442 (+1) | 36 kDa | 1 | Q9WUM5 | Suclg1 |
| LYR motif-containing protein 4 | IPI00169804 | 11 kDa | 1 | Q8K215 | Lyrm4 |
| Phosphorylase b kinase regulatory subunit beta | IPI00380735 | 124 kDa | 1 | Q7TSH2 | Phkb |
| Dihydropyrimidinase-related protein 2 | IPI00114375 | 62 kDa | 1 | O08553 | Dpysl2 |
| Creatine kinase B-type | IPI00136703 | 43 kDa | 1 | Q04447 | Ckb |