Martinez‐Sanchez 2015.

Study characteristics
Patient sampling
Patient characteristics and setting	65 participants (mean age 63.8) Geographical location: Spain
Index tests	TCCD
Target condition and reference standard(s)	Occlusion of MCA Reference standard: CTA
Flow and timing	Timing < 8 hours
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	Unclear
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Unclear
		Unclear	Unclear
DOMAIN 2: Index Test Index test
If a TCD/TCCD threshold was used, was it pre‐specified e.g. MFV thresholds ranging from ≥ 80 cm/s to ≥ 120 cm/s and ≥ 120 cm/s to ≥ 230 cm/s?	Yes
		Unclear	Unclear
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	Yes
		Unclear	Unclear
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Were all patients included in the analysis?	Yes
		Low