Table 2.

Parkinsonism-hyperpyrexia and serotonin syndromes

Parkinsonism-hyperpyrexia syndrome	Serotonin syndrome
Muscle rigidity, prominent akinesia	Tremor, myoclonus, akathisia, hypertonicity
Altered mental status Hyperthermia Rhabdomyolysis
Trigger factors
Infection, trauma, medication changes	Drug combinations: MAO inhibitor, SSRI, tricyclic antidepressant, opioids
Treatment
Escalating dopaminergic treatment	Stopping the causative drug
Supportive intensive care management

MAO, monoamine oxidase B; SSRI, selective-serotonin reuptake inhibitor.