Table 3.

Complications in the setting of device-aided therapies

	Deep-brain stimulation	Levodopa-carbidopa intestinal gel	Apomorphine
Procedure	Surgery	Percutaneous endoscopy gastrostomy	Subcutaneous infusion
	Intracranial haemorrhage Venous infarction Pneumoencephalus Dyskinesia storm Air embolus	Pneumoperitoneum Peritonitis Gastrointestinal haemorrhage	Not described
Device	Hardware-related	Gastrointestinal pump	Pump
	Infection of external system Skin erosions at the level of the neurostimulator Fracture of extension wire End of life battery Accidental stimulator switch off (eg, environmental factors such as magnetic forces)	Breakdown of connexions Unintentional removal Obstruction of the intraduodenal tube (eg, kinking) Pressure ulcers of intraduodenal tube on intestinal wall Bezoar Pump dysfunction	Subcutaneous nodules Pump dysfunction
Treatment	Stimulation	Levodopa-carbidopa gel	Apomorphine
	Dyskinesia storm Gait unsteadiness Worsening of dysarthria Behavioural changes, hypomania, depression	Unpredictable offs Biphasic dyskinesias Confusion, hallucinations Malabsorption (B12, B6 vitamin deficiency), polyneuropathy, Guillain-Barré-like syndrome	Nauseas Hypotension Daytime somnolence Confusion, hallucinations Unpredictable offs Dyskinesias Haemolytic anaemia Eosinophilic syndrome