Table 6.
Comparison of phase I designs under dose-toxicity Scenario 5.
| Dose | DLT rate | Designs |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 + 3 | 3 + 3@9,2 | CS(40; 3,6,9) | CS(25; 5,11) | CS(35; 2,6) | CS(50; 1,3,5) | CS(50) | mTPI | mTPI2 | CRM | ||
| Proportion of recommended dose (MTD) dose levels (%) | |||||||||||
| 0 | 83 | 96 | 88 | 99 | 82 | 40 | 49 | 26 | 12 | 0 | |
| 1 | 0.45 | 16 | 4 | 11 | 1 | 16 | 31 | 32 | 67 | 74 | 80 |
| 2 | 0.55 | 1 | 0 | 1 | 0 | 2 | 17 | 13 | 6 | 14 | 18 |
| 3 | 0.60 | 0 | 0 | 0 | 0 | 0 | 12 | 6 | 0 | 0 | 2 |
| Proportion of patients treated (%) | |||||||||||
| 1 | 0.45 | 90 | 91 | 94 | 99 | 87 | 59 | 64 | 91 | 91 | 75 |
| 2 | 0.55 | 9 | 8 | 6 | 1 | 12 | 25 | 21 | 9 | 9 | 24 |
| 3 | 0.60 | 1 | 1 | 0 | 0 | 2 | 17 | 15 | 0 | 0 | 1 |
| Average number of patients | 4.7 | 5.1 | 5.0 | 3.3 | 5.1 | 7.0 | 12.5 | 5.7 | 5.7 | 6.0 | |
| Percent toxicity (%) | 59.9 | 60.4 | 59.9 | 62.3 | 58.1 | 59.6 | 60.8 | 46.0 | 46.0 | 47.5 | |