Table 8.

Application of the designs to data generated according to the trial in Simon et al. [7] CS(25) represents CS(25; 5,11), and CS(35) represents CS(35; 2,6).

	Design
	3 + 3	3 + 3@9,2	CS(40; 3,6,9)	CS(25)	CS(35)	CS(50; 1,3,5)	CS(50)	mTPI	mTPI2	CRM
Patients enrolled	17	20	20	27	13	11	15	18	18	17
DLT rate at $\widehat{\text{MTD}}$ (%)	32	32	32	14	14	32	32	32	32	32
% with a DLT	18	15	15	11	23	18	40	17	17	29
% treated at $\widehat{\text{MTD}}$	35	45	45	41	46	45	67	33	33	76
% treated within 1 level of $\widehat{\text{MTD}}$	65	70	70	81	85	82	87	67	67	94