Table 2.

Test characteristics of ARR to screen for PA according to stratified GFR.

eGFR	Optimal cut-off	Sensitivity (95% CI)	Specificity (95% CI)	Positive LR (95% CI)	Negative LR (95% CI)
ALL	18	100.0 (95.4–100.0)	71.38 (67.6–75.0)	3.5 (3.1–4.0)	—
	40	92.4 (84.2–97.2)	90.3 (87.7–92.6)	9.6 (7.4–12.3)	0.1 (0.0-0.1)
	52	82.3 (72.1–90.0)	94.7 (92.6–97.3)	15.5 (10.9–22.0)	0.2 (0.1–0.3)
<90	18	100.0 (87.2–100.0)	95.3 (92.0–97.6)	21.3 (12.3–37.1)	—
	40	85.2 (66.3–95.8)	100.0 (98.6–100.0)	—	0.2 (0.1–0.4)
	52	85.2 (66.3–95.8)	100.0 (98.6–100.0)	—	0.2 (0.1–0.4)
≥90	18	100.0 (93.2–100.0)	90.7 (87.2–93.6)	10.8 (7.8–15.0)	—
	40	100.0 (93.2–100.0)	90.7 (87.2–93.6)	10.8 (7.8–15.0)	—
	52	98.1 (89.7–100.0)	95.4 (92.6–97.3)	21.2 (13.1–34.2)	0.0 (0.0-0.1)

ARR, aldosterone-to-renin ratio; eGFR, estimated glomerular filtration rate; PA, primary aldosteronism; LR, likelihood ratios; CI, confidence interval.