Table 4.
Determination of ciprofloxacin, ofloxacin, and levofloxacin in pharmaceutical formulations.
Analytes | Tissue | Original (mg·mL−1) | Found (mg·mL−1) | RSD (n = 5%) | Content (μg·mL−1) | Added (μg·mL−1) | Found (μg·mL−1) | Recovery (n = 5%) |
---|---|---|---|---|---|---|---|---|
CIP | Infusion | 2 | 1.99 ± 0.003 | 1.91 | 0.04 ± 1.99 | 1 | 0.05 ± 3.01 | 102 ± 3 |
1.92 ± 0.036 | 1.34 | 0.03 ± 1.92 | 3 | 0.19 ± 5.01 | 103 ± 2 | |||
1.96 ± 0.016 | 1.06 | 1.96 ± 0.02 | 5 | 0.09 ± 6.97 | 100 ± 2 | |||
| ||||||||
CIP | Eye drop | 3 | 2.91 ± 0.028 | 8.80 | 0.17 ± 1.94 | 1 | 0.23 ± 3.02 | 108 ± 4 |
2.93 ± 0.054 | 7.96 | 0.16 ± 1.95 | 3 | 0.14 ± 5.03 | 102 ± 3 | |||
2.98 ± 0.006 | 5.68 | 0.11 ± 1.98 | 5 | 0.08 ± 7.01 | 100 ± 3 | |||
| ||||||||
CIP | Tablet | 2.5 | 2.47 ± 0.009 | 7.06 | 0.14 ± 1.98 | 1 | 0.23 ± 2.96 | 98 ± 4 |
2.47 ± 0.010 | 4.34 | 0.09 ± 1.97 | 3 | 0.17 ± 5.10 | 104 ± 5 | |||
2.41 ± 0.03 | 6.71 | 0.13 ± 1.93 | 5 | 0.21 ± 6.89 | 99 ± 4 | |||
| ||||||||
OFLX | Tablet | 2 | 1.98 ± 0.006 | 7.24 | 0.14 ± 1.98 | 1 | 0.15 ± 2.97 | 98 ± 4 |
1.91 ± 0.043 | 7.63 | 0.15 ± 1.91 | 3 | 0.19 ± 5.06 | 104 ± 5 | |||
1.95 ± 0.022 | 6.24 | 0.12 ± 1.95 | 5 | 0.19 ± 6.98 | 99 ± 4 | |||
| ||||||||
Levo | Tablet | 5 | 5.37 ± 0.075 | 5.81 | 0.13 ± 2.15 | 1 | 0.35 ± 3.17 | 102 ± 4 |
5.32 ± 0.064 | 5.35 | 0.11 ± 2.12 | 3 | 0.29 ± 5.21 | 103 ± 4 | |||
5.17 ± 0.034 | 7.39 | 0.15 ± 2.06 | 5 | 0.12 ± 7.17 | 102 ± 3 | |||
| ||||||||
Levo | Eye drop | 5 | 5.38 ± 0.077 | 5.01 | 0.11 ± 2.15 | 1 | 0.26 ± 3.13 | 98 ± 4 |
5.18 ± 0.036 | 5.83 | 0.12 ± 2.07 | 3 | 0.16 ± 5.11 | 101 ± 4 | |||
5.23 ± 0.046 | 7.54 | 0.16 ± 2.09 | 5 | 0.17 ± 7.08 | 100 ± 4 |