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. 2020 Feb 7;2020:4235909. doi: 10.1155/2020/4235909

Figure 2.

Figure 2

Its cytokine production in the blood serum. (a) In the clinical study, the higher levels of TNF-α, IL-1β, IL-6, IL-18, CCL3, and CCL5 except for IL-10 in the early phase of sepsis compared with the late phase of sepsis and the healthy participants, n = 30. ∗∗P < 0.01 represented the significant difference; ##P < 0.01: compared with the healthy participants, the difference was of significance. (b) Ade-HIF-1α injection increased the production of TNF-α, IL-1β, IL-6, IL-18, CCL3, and CCL5 except for IL-10 in the late stage of the sepsis rat model. ∗∗P < 0.01: compared with the normal control group, the difference was of significance; #P < 0.05: compared with the sepsis rat model group and the adenovirus control group; &P < 0.05: compared with the sepsis rat model group. Besides, data were presented as mean ± standard deviation, and data was repeated in triplicate.