Table 1.

Overview and possible limitations of a selection of longitudinal studies with brain donation end-points

Study	Commenced	Cohort size	Recruitment age	Cognitive status of participants	Limitations of study
MRC CFAS [1, 2]	1989	18000	65+	Normal/C.I.	Sampling strategy led to cohort of older and more cognitively impaired individuals when compared with the general population
Nun study [3]	1986	678	75+	Random	Selected cohort (female only)
Religious Orders Study [4]	1994	1000+	Aged	Normal	Selected cohort (male only)
BLSA [5]	1958	1400	20 – 90	Normal	Sampling strategy led to cohort of predominantly male, white well educated individuals
HAAS [7]	1991-2012	3734	71 – 93	Random	Selected cohort (Japanese-American males)
Vantaa 85 + [9]	1991	601	85+	Random	Selectively population-based (South Finland)
ACT [10]	1994	2581	65+	Random	Selected cohort (King’s County, WA)