Table 3.
Biomarkers and MCI at baseline in PD participants
| Cognitively Normal | MCI at Baseline | ||||
| N = 80 | N = 61 | p | |||
| Median [IQR] | Missing | Median [IQR] | Missing | ||
| TL Baseline (T/S ratio) | 0.77 [0.58,0.90] | 21.25% | 0.79 [0.64,0.93] | 22.95% | |
| p21 Baseline (A.U.) | 1.34 [0.93,1.98] | 6.25% | 1.03 [0.74,1.49] | 4.92% | p = 0.012a |
| p16 Baseline (A.U.) | 1.14 [0.74,1.74] | 6.25% | 1.29 [0.77,1.80] | 4.92% | |
| CRP (ng/ml) | 1.10 [0.41,2.85] | 12.50% | 2.20 [0.82,5.26] | 14.75% | p = 0.015a |
| TNF alpha (pg/ml) | 2.74 [2.21,3.41] | 12.50% | 3.25 [2.51,3.78] | 14.75% | |
| IL-6 (pg/ml) | 0.58 [0.36,0.87] | 15.00% | 0.78 [0.58,1.34] | 14.75% | p = 0.003a |
| IL-10 (pg/ml) | 0.23 [0.17,0.35] | 17.50% | 0.26 [0.17,0.39] | 16.39% | |
| IFNg (pg/ml) | 5.78 [4.18,8.04] | 12.50% | 6.46 [4.88,11.23] | 14.75% | |
| Inflammatory score | –0.27 [–0.89,0.54] | 20.00% | 0.51 [–0.44,2.24] | 16.39% | p = 0.006a |
aIndependent-Samples Mann-Whitney U test significant after Benjamini-Hochberg multiple test correction. †For this composite variable, larger value = lower telomere shortening rate, see text.