Table 4.

Linear regression modelling on biomarkers and disease progression in Parkinson’s disease participants^*

Baseline Biomarkers		TL (T/S ratio)		p21 expression (A.U.)		p16 expression (A.U.)		Inflammatory Score
		Beta	p value	Beta	p value	Beta	p value	Beta	p value
MDS-UPDRS-III	at 36 months	–0.068	0.477	0.021	0.811	–0.175	0.051	0.174	0.079
	change rate over 36 months	–0.020	0.832	0.110	0.216	–0.218	0.014	–0.004	0.970
MMSE	at 36 months	0.149	0.134	–0.009	0.922	0.080	0.409	–0.068	0.512
	change rate over 36 months	0.043	0.682	–0.031	0.751	0.120	0.231	0.116	0.287
MoCA	at 36 months	0.106	0.262	0.008	0.934	0.080	0.389	–0.205	0.037
	change rate over 36 months	0.066	0.560	–0.070	0.516	0.311	0.003	0.055	0.653

^*All models adjusted for age, gender, baseline LEDD and BMI.