Table 5.

Logistic Regression modelling on biomarkers and motor impairment (HY 3 or above) at 36 months follow-up

Baseline Biomarkers			TL (T/S ratio)		p21 expression (A.U.)		p16 expression (A.U.)		Inflammatory Score
			O.R.	p value	O.R.	p value	O.R.	p value	O.R.	p value
Motor Impairment	at 36 monthsa		0.217	0.273	1.000	0.698	0.988	0.831	1.006	0.939
	Change over 36 monthsb	Motor Improvement	0.383	0.534	0.415	0.171	0.995	0.805	1.086	0.367
		Motor Impairment	0.535	0.748	1.000	0.941	0.471	0.288	1.110	0.374

O.R., Odds Ratio; ^aBinary Logistic Regression. ^bMultinomial Logistic Regression. Reference category: No Change from Baseline to 36 months follow-up; Motor Improvement: from HY≥3 to HY < 3; Motor Impairment: from HY < 3 to HY≥3. All models adjusted for age, gender, baseline LEDD and BMI.