Fig.2.

Statistical assessment of APOE ɛ4 and two different Aβ predictors on glucose metabolism. A) Cortical surface projections of t-statistic maps for the main effect of APOE ɛ4. FDR-based thresholding showed no significant regions. FDR-thresholded statistically significant regions for the main effect of SVD-based Aβ scores (B) and composite ROI amyloid burden (C) as predictors of cortical metabolism. The effect of composite ROI Aβ burden on metabolism is less spatially extended compared to the SVD-based Aβ score, particularly in the bilateral right angular gyrus, inferior temporal gyrus, and precuneus. D) Regions surviving FDR thresholding for the main effect of SVD-based Aβ scores corresponding to the LMCI cohort. Significant regions appear to be weaker and less spatially extended as compared to the whole sample.