Table 1.
Patient characteristics.
| Patient | Age | Sex | Sample type | Clinical classification of uveitis (IUSG, 2005) | Anatomic classification of uveitis | Notes |
|---|---|---|---|---|---|---|
| P1 | 28 | F | Enucleation | Non-infectious, no known systemic association | Panuveitis | Idiopathic uveitis. Enucleation for blind painful eye. |
| P2 | 29 | F | Enucleation | Non-infectious, no known systemic association | Panuveitis | History of scleritis and episcleritis in addition to uveitis. Enucleation for blind painful eye. |
| P3 | 26 | F | Enucleation | Non-infectious, no known systemic association | Panuveitis | Idiopathic uveitis complicated by glaucoma |
| P4 | 17 | M | Enucleation | Non-infectious, known systemic association | Panuveitis | Clinical diagnosis of probable Behcet's disease-associated uveitis, no systemic features of Behcet's disease, HLA B51+. Enucleation for blind painful eye. |
| P5 | 61 | F | Enucleation | Non-infectious, no known systemic association | Panuveitis | Idiopathic uveitis. Enucleation for suspected sympathetic ophthalmia following multiple intraocular surgeries but histological features not diagnostic of SO. |
| P6 | N/A | F | Evisceration | N/A | Panuveitis | N/A |
| P7 | N/A | F | Enucleation | Non-infectious, no known systemic association | Intermediate | Idiopathic uveitis |
| P8 | 38 | M | Enucleation | Non-infectious, known systemic association | Panuveitis | Behcet's disease-associated uveitis |
| P9 | 74 | F | Enucleation | Non-infectious, no known systemic association | Panuveitis | Idiopathic uveitis |
| P10 | 70 | F | Enucleation | Non-infectious, known systemic association | Panuveitis | Systemic granulomatosis with polyangiitis (Wegener's granulomatosis) with scleritis and uveitis |
| P11 | 26 | F | Enucleation | Non-infectious, known systemic association | Anterior | Juvenile idiopathic arthritis-associated uveitis |
| P12 | 34 | M | Evisceration | Non-infectious, no known systemic association | Posterior | Idiopathic uveitis |
| P13 | 33 | M | Evisceration | Non-infectious, no known systemic association | Posterior | Idiopathic uveitis |
| P14 | 77 | F | Enucleation | Non-infectious, no known systemic association | Panuveitis | Idiopathic uveitis |
| P15 | 50 | M | Enucleation | Non-infectious, no known systemic association | Panuveitis | Idiopathic uveitis |
Formalin-fixed paraffin-embedded enucleated or eviscerated human eyes, from 15 patients with uveitis, were obtained from the Liverpool Ocular Oncology Biobank (Liverpool, UK) and Moorfields Biobank (London, UK) with ethical approval. Samples were identified by reviewing histopathology reports from each institution and selected if reported to contain features of chronic inflammation i.e. visible lymphocytes within the uvea or retina on haematoxylin- and eosin-staining. All patients had a persistent, chronic clinical course of disease. The duration of clinical disease could not be ascertained from the limited notes available and neither could we completely rule out a history of ocular infections.