Table 2.
Characteristics of CD20 infiltrate.
| Subject | CD20 + infiltrate |
Tissue(s) affected |
Notes |
|||
|---|---|---|---|---|---|---|
| Diffuse | Focal | ELS like | AID positive | |||
| P1 | + | + | + | + | Iris, ciliary body, choroid | B cell follicles in iris, ciliary body, and choroid; x/y follicles displaying GC markers |
| P2 | + | + | + | – | Choroid, sclera | B cell follicles in choroid and sclera; x/y follicles displaying GC markers |
| P3 | + | + | + | + | Choroid | B cell follicles in choroid; x/y follicles displaying GC markers |
| P4 | + | + | – | – | Iris, ciliary body, choroid | Significant CD20 + infiltrate in iris, ciliary body and choroid with focal aggregations of CD20 + cells but no other features of ELS |
| P5 | + | – | – | – | Iris, ciliary body and choroid | Dense diffuse infiltrate in iris, ciliary body and choroid but no focal aggregations of CD20 + cells or other features of ELS |
| P6 | + | + | – | – | Choroid | CD20 + infiltrate present in choroid with focal aggregations of CD20 + cells proximal to focal aggregations of CD3+ cells but no clear segregation into B and T cell zones |
| P7 | + | – | – | – | Iris, choroid | Sparse diffuse CD20 + infiltrate in choroid |
| P8 | + | – | – | – | Choroid | Sparse diffuse CD20 + infiltrate in choroid |
| P9 | + | + | – | – | Choroid | Small focal CD20 + aggregations in choroid |
| P10 | – | – | – | – | N/A | No CD20 + infiltrate present |
| P11 | – | – | – | – | N/A | No CD20 + infiltrate present |
| P12 | – | – | – | – | N/A | No CD20 + infiltrate present |
| P13 | + | + | – | – | Retina, choroid | 2 small focal aggregations of CD20 + cells, 1 in retina (appears perivascular) and 1 in choroid |
| P14 | + | + | – | – | Choroid | 3 small focal aggregations of CD20 + cells in choroid |
| P15 | – | – | – | – | N/A | |
Infiltrate was classified on the basis of CD20 infiltration as diffuse or focal. ELS was defined as: Focal CD20 + aggregations with CD20/CD3 segregation, CD21 + network(s), CD23 + cells within areas of CD20 + focal aggregation and BCL6+ cells within area of CD20 + aggregation. Within ELS like tissue, focal aggregates were tested for AID expression.