Table 1.
Demographic and clinical characteristics, laboratory tests, and severity scores of patients on admission
| Characteristic | All patients (n = 1281) | Without BI (n = 921) | With BI (n = 360) | P value |
| Median age (IQR) -yr | 51 (42-57) | 52 (43-57) | 50 (42-57) | 0.16 |
| Male sex (%) | 1012 (79) | 726 (78.8) | 286 (79.4) | 0.88 |
| Concomitant etiology of cirrhosis (%) | ||||
| Alcohol | 142 (11.1) | 102 (11.1) | 40 (11.1) | 1.00 |
| Others | 48 (3.7) | 36 (3.9) | 12 (3.3) | 0.74 |
| HBeAg positive HBV (%)1 | 421/1122 (37.5) | 298/794 (37.5) | 123/328 (37.5) | 1.00 |
| Experience of anti-HBV treatment (%)1 | 284/1176 (24.2) | 183/851 (21.5) | 101/325 (31.1) | < 0.001 |
| Decompensations (%)2 | ||||
| Ascites | 1099 (85.8) | 773 (83.9) | 326 (90.6) | < 0.01 |
| Jaundice | 534 (41.7) | 297 (32.2) | 237 (65.8) | < 0.001 |
| Gastrointestinal variceal bleeding | 336 (26.2) | 280 (30.4) | 56 (15.6) | < 0.001 |
| Hepatic encephalopathy | 190 (14.8) | 82 (8.9) | 108 (30) | < 0.001 |
| ACLF at admission (%) | 284 (22.2) | 130 (14.1) | 154 (42.8) | < 0.001 |
| Median value for laboratory tests (IQR) | ||||
| Log10 HBV DNA (copies/mL)3 | 4.7 (3.1-6.1) | 4.8 (3-6.2) | 4.6 (3.1-5.7) | 0.33 |
| Hemoglobin (g/L) | 103 (83-121) | 102 (82-119) | 107 (87-127) | < 0.001 |
| White cell count: × 109 cells/L | 4.7 (2.9-7.5) | 4.2 (2.7-6.1) | 6.9 (4.3-10.9) | < 0.001 |
| Platelet count: × 109 cells/L | 63 (40-102) | 60 (40-96) | 70 (42-117.5) | < 0.01 |
| International normalized ratio | 1.6 (1.3-2) | 1.4 (1.3-1.9) | 1.8 (1.5-2.6) | < 0.001 |
| Serum sodium (mmol/L) | 136 (131.2-139) | 136 (132.3-139.3) | 134 (129-137) | < 0.001 |
| Serum creatinine (mg/dL) | 0.8 (0.7-1) | 0.8 (0.7-1) | 0.8 (0.6-1.1) | 0.20 |
| Aspartate aminotransferase (IU/L) | 67 (42-124) | 60 (40-107) | 97 (56.5-192) | < 0.001 |
| Alanine aminotransferase (IU/L) | 47 (30-97) | 42 (29-80) | 67 (37-185.8) | < 0.001 |
| Total bilirubin (mg/dL) | 3.4 (1.5-15.5) | 2.6 (1.4-8) | 10.9 (3-27.4) | < 0.001 |
| Serum albumin (g/dL) | 2.8 (2.5-3.2) | 2.9 (2.5-3.3) | 2.8 (2.4-3.1) | < 0.001 |
| Median value for severity scores (IQR) | ||||
| Child-Pugh | 11 (9-12) | 10 (8-12) | 12 (10-13) | < 0.001 |
| MELD | 16.8 (11.8-25.5) | 14.8 (11.1-22.3) | 24.4 (17.1-30.2) | < 0.001 |
1
Number/number of patients with available data.
2
Some patients had more than one decompensating event.
3
Analysis was performed in 1031 patients with available data. IQR: Interquartile range; ACLF: Acute-on-chronic liver failure; MELD: Model for end stage liver disease; HBV: Hepatitis B virus.