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. 2020 Feb 12;10:1648. doi: 10.3389/fphar.2019.01648

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Copyright © 2020 Jæger, Charwat, Charrez, Finsberg, Maleckar, Wall, Healy and Tveito

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AP, cytosolic Ca²⁺ transient and major ionic currents in the hiPSC-CM and adult versions of the base model. In the left panel, the base model is adjusted to fit data obtained from optical measurements of the AP and Ca²⁺ transient of hiPSC-CMs. In the right panel, the base model is adjusted to approximate the Grandi et al. (2010) model of adult cardiomyocytes.