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. 2020 Feb 12;10:1648. doi: 10.3389/fphar.2019.01648

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Copyright © 2020 Jæger, Charwat, Charrez, Finsberg, Maleckar, Wall, Healy and Tveito

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification and mapping of drug effects for the drug Nifedipine based on optical measurements of the AP and Ca²⁺ transient of hiPSC-CMs. (A) AP and Ca²⁺ transient in the control case and for four drug doses for the data (left) and the fitted hiPSC-CM model (center). The predicted drug effects for adult cardiomyocytes are given in the right panel (note that the scaling of the axes is adjusted for the adult case). Note also that, to clearly see differences in the Ca²⁺ transient amplitude, the displayed Ca²⁺ concentrations are adjusted so that the Ca²⁺ transient amplitude is preserved, but the resting concentration is set to zero in each case. (B) Drug effect on I_CaL, I_NaL and I_Kr in the form of ε-values estimated by the inversion procedure. (C) Comparison between the measured membrane potential and Ca²⁺ traces and the fitted model solutions for each of the doses in the data set.