Table 2.
Comparison between the IC50 values obtained from the inversion procedure and values found in literature.
Nifedipine | Lidocaine | Cisapride | Flecainide | Verapamil | ||
---|---|---|---|---|---|---|
CaL | Inversion | 38 nM | 3400 μM | 775 nM | 9 μM | 495 nM |
Literature | 12 nM (Kramer et al., 2013) | 11 800 nM (Kramer et al., 2013) | 26 μM (Crumb et al., 2016) | 202 nM (Crumb et al., 2016) | ||
60 nM (Di Stilo et al., 1998) | 27 μM (Kramer et al., 2013) | 200 nM (Kramer et al., 2013) | ||||
100 nM (Mirams et al., 2011) | ||||||
NaL | Inversion | 23 600 nM | 4.3 μM | 120 nM | 47 μM | 23 000 nM |
Literature | 11 μM (Crumb et al., 2016) | 19 μM (Crumb et al., 2016) | ||||
Kr | Inversion | 40 200 nM | 50 000 μM | 13 nM | 1.9 μM | 2150 nM |
Literature | 440 000 nM (Kramer et al., 2013) | 12 nM (Crumb et al., 2016) | 0.7 μM (Crumb et al., 2016) | 499 nM (Crumb et al., 2016) | ||
275 000 nM (Zhabyeyev et al., 2013) | 20 nM (Kramer et al., 2013) | 1.5 μM (Kramer et al., 2013) | 250 nM (Kramer et al., 2013) | |||
6.5 nM (Mohammad et al., 1997) | 143 nM (Zhang et al., 1999) |