Table 1.
Demographic data
| Group | N | Age | MMSE score | Male sex, % | APOE ɛ4, % | Education, y | F-U time, months | WMC volume, cm3 | Vascular burden, % |
| AD | 83 | 67.2±7.1 | 23.5±3.5† | 29 | 67† | 10.8±3.5† | 15.5±17.3 | 4.3±2.9 | 13 |
| Mixed | 46 | 71.2±6.0† | 23.8±3.0† | 30† | 67† | 10.7±3.4 | 11.5±16.8 | 9.0±6.1 | 46 |
| SVD | 23 | 70.3±7.1† | 25.0±2.3† | 74† | 39 | 11.4±3.3 | 14.8±17.2 | 17.0±9.4† | 78† |
| Controls | 126 | 65.4±7.5 | 29.4±1.2 | 38 | 32 | 12.2±2.9 | 10.2±19.8 | 4.1±6.1 | 19 |
| MCI-AD | 43 | 66.1±6.4 | 27.8±1.3 | 44 | 72* | 11.8±3.5 | 27.1±12.3 | 4.3±6.9 | 22 |
| MCI-Mix | 26 | 70.0±6.3* | 26.9±2.2* | 31 | 69* | 11.2±4.1 | 25.7±9.7 | 8.0±5.3 | 38 |
| MCI-SVD | 16 | 68.8±7.5 | 28.3±1.7 | 56 | 50 | 11.9±3.8 | 38.7±29.9 | 23.8±7.8* | 94* |
| MCI-MCI | 130 | 65.4±8.1 | 28.3±1.5 | 44 | 38 | 11.3±3.4 | 37.8±25.3 | 5.4±6.6 | 38 |
Dementia groups (AD, Mixed, and SVD) were compared with controls. Converting MCI subgroups (MCI-AD, MCI-Mix, and MCI-SVD) were compared with MCI-MCI. APOE ɛ4 %, Percentage of study participant with at least one APOE ɛ4 allele; F-U time, follow up time (time until conversion for converting MCI groups, total follow up time for the other groups); WMC volume, white matter changes volume; Vascular burden, Percentage of study participants with at least two vascular risk factors and not insignificant WMCs. †p-value<0.05 versus Controls after Bonferroni correction. *p-value<0.05 versus MCI-MCI after Bonferroni correction.