Table 3.
Predictive values
| MCI-AD versus MCI-MCI | MCI-mix versus MCI-MCI | MCI-SVD versus MCI-MCI | |
| Aβ42 | |||
| AUC (Sens, spec) % | 69 (67, 70) | 72 (64, 70) | 62 (94, 29) |
| Pos LR (95% CI) | 2.2 (1.6-3.2) | 2.8 (2.0-3.9) | 1.3 (1.1-1.6) |
| Odds ratio (95% CI) | 4.2 (2.2-7.7) | 5.7 (2.3-14.1) | 1.8 (0.9-3.5) |
| T-tau | |||
| AUC (Sens, spec) % | 78 (81, 77) | 75 (60, 78) | 63 (92, 23) |
| Pos LR (95% CI) | 3.6 (2.4-5.2) | 2.7 (1.7-4.4) | 1.4 (1.1-1.7) |
| Odds ratio (95% CI) | 4.0 (2.1-7.6) | 3.8 (1.9-7.4) | 1.1 (0.4-2.7) |
| P-tau | |||
| AUC (Sens, spec) % | 79 (67, 84) | 81 (45, 89) | 55 (85, 40) |
| Pos LR (95% CI) | 4.2 (2.5-6.9) | 4.1 (2.0-8.5) | 1.4 (1.1-1.9) |
| Odds ratio (95% CI) | 6.1 (3.1-11.8) | 2.6 (1.3-5.2) | 2.1 (0.6-6.8) |
| Left HC | |||
| AUC (Sens, spec) % | 67 (47, 71) | 69 (91, 64) | |
| Pos LR (95% CI) | 1.7 (0.9-3.0) | 2.6 (1.8-3.6) | |
| Odds ratio (95% CI) | 1.5 (0.9-2.4) | 3.0 (1.5-6.0) | |
| 3rd ventricle | |||
| AUC (Sens, spec) % | 56 (53, 57) | ||
| Pos LR (95% CI) | 1.2 (0.7-2.1) | ||
| Odds ratio (95% CI) | 1.2 (0.7-2.0) | ||
| Left ERC | |||
| AUC (Sens, spec) % | 68 (36, 75) | ||
| Pos LR (95% CI) | 1.45 (0.6-3.3) | ||
| Odds ratio (95% CI) | 1.1 (0.6-2.2) | ||
| Right caudate volume | |||
| AUC (Sens, spec) % | 80 (27, 87) | ||
| Pos LR (95% CI) | 2.1 (0.7-6.3) | ||
| Odds ratio (95% CI) | 1.8 (0.98-3.4) | ||
| Right paracentral volume | |||
| AUC (Sens, spec) % | 60 (80, 25) | ||
| Pos LR (95% CI) | 1.1 (0.8-1.5) | ||
| Odds ratio (95% CI) | 1.2 (0.7-1.8) | ||
| RAVLT TL | |||
| AUC (Sens, spec) % | 75 (44, 87) | ||
| Pos LR (95% CI) | 3.3 (1.8-6.0) | ||
| Odds ratio (95% CI) | 4.1 (2.1-8.2) | ||
| RAVLT DR | |||
| AUC (Sens, spec) % | 74 (72, 75) | ||
| Pos LR (95% CI) | 2.8 (1.9-4.2) | ||
| Odds ratio (95% CI) | 5.4 (2.3-12.4) | ||
| F-A-S | |||
| AUC (Sens, spec) % | 56 (38, 63) | ||
| Pos LR (95% CI) | 1.0 (0.7-1.6) | ||
| Odds ratio (95% CI) | 1.4 (0.8-2.3) | ||
| RCF copy | |||
| AUC (Sens, spec) % | 74 (38, 85) | ||
| Pos LR (95% CI) | 2.6 (1.4-4.9) | ||
| Odds ratio (95% CI) | 1.8 (1.2-2.9) | ||
| Token test | |||
| AUC (Sens, spec) % | 73 (65, 75) | ||
| Pos LR (95% CI) | 2.6 (1.6-4.0) | ||
| Odds ratio (95% CI) | 3.0 (1.5-6.0) | ||
| TMT A | |||
| AUC (Sens, spec) % | 70 (78, 69) | ||
| Pos LR (95% CI) | 2.5 (1.5-4.2) | ||
| Odds ratio (95% CI) | 6.9 (2.0-24.7) |
AUC, area under the curve; Sens, sensitivity; Spec, specificity; Pos LR, positive likelihood ratio; CI, confidence interval; Left HC, left hippocampal volume; Left ERC, left entorhinal cortex volume.