Table 1.
Description of study participants at MOUTH (or HOTSPOT) study baseline, by study population
| N (%) | |||||
|---|---|---|---|---|---|
| HOTSPOT Study |
MOUTH Study |
||||
| HPV-OPC Cases N = 133 |
Controlsa N = 134 |
At-risk (MOUTH screening) N = 294 |
High-risk (HIV-positive CCS)b N = 100 |
High-risk (HIV-negative CCS) N = 33 |
|
| Sex | |||||
| Male | 119 (89.5%) | 18 (13.4%) | 261 (88.8%) | 49 (49.0%) | 17 (51.5%) |
| Female | 14 (10.5%) | 116 (86.6%) | 33 (11.2%) | 51 (51.0%) | 16 (48.5%) |
| Age in years: | |||||
| Median (IQR) | 55 (50, 60) | 51 (45, 59) | 55 (48, 62) | 56 (50, 61) | 57 (48, 62) |
| Race | |||||
| White | 122 (91.7%) | 115 (85.8%) | 238 (81.0%) | 36 (36.0%) | 12 (36.4%) |
| Black | 6 (4.5%) | 7 (5.2%) | 38 (12.9%) | 56 (56.0%) | 18 (54.6%) |
| Other | 0 (0.0%) | 6 (4.5%) | 18 (6.1%) | 8 (8.0%) | 3 (9.1%) |
| Missing | 5 (3.8%) | 6 (4.5%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| Education level | |||||
| <High-school | 4 (3.0%) | 3 (2.2%) | 8 (2.7%) | 18 (18.0%) | 6 (18.2%) |
| High school/GED | 52 (39.1%) | 40 (29.9%) | 77 (26.2%) | 48 (48.0%) | 14 (42.4%) |
| College | 47 (35.3%) | 49 (36.6%) | 83 (28.2%) | 20 (20.0%) | 6 (18.2%) |
| Adv/Degree | 17 (12.8%) | 34 (25.4%) | 124 (42.2%) | 14 (14.0%) | 6 (18.2%) |
| Missing | 13 (9.8%) | 8 (6.0%) | 2 (0.7%) | 0 (0.0%) | 1 (3.0%) |
| Marital status | |||||
| Married | 107 (80.5%) | 116 (86.6%) | 224 (76.2%) | 31 (31.0%) | 13 (39.4%) |
| Sep/Div/Widow | 13 (9.8%) | 5 (3.7%) | 39 (13.3%) | 21 (21.0%) | 11 (33.3%) |
| Single | 8 (6.0%) | 12 (9.0%) | 29 (9.9%) | 48 (48.0%) | 9 (27.3%) |
| Missing | 5 (3.8%) | 1 (0.7%) | 2 (0.7%) | 0 (0.0%) | 0 (0.0%) |
| Smoking status | |||||
| Never | 66 (49.6%) | 67 (50.0%) | 174 (59.2%) | 31 (31.0%) | 11 (33.3%) |
| Former | 43 (32.3%) | 45 (33.6%) | 95 (32.3%) | 27 (27.0%) | 9 (27.3%) |
| Current | 17 (12.8%) | 12 (9.0%) | 23 (7.8%) | 41 (41.0%) | 13 (39.4%) |
| Missing | 7 (5.3%) | 10 (7.5%) | 2 (0.7%) | 1 (1.0%) | 0 (0.0%) |
| Ever alcohol use | |||||
| No | 23 (17.3%) | 46 (34.3%) | 45 (15.3%) | 38 (38.0%) | 8 (24.2%) |
| Yes | 105 (78.9%) | 78 (58.2%) | 246 (83.7%) | 56 (56.0%) | 23 (69.7%) |
| Missing | 5 (3.8%) | 10 (7.5%) | 3 (1.0%) | 6 (6.0%) | 2 (6.1%) |
| Number of lifetime oral sexual partners | |||||
| 0 | 2 (1.5%) | 6 (4.5%) | 3 (1.0%) | 10 (10.0%) | 2 (6.1%) |
| 1 | 9 (6.8%) | 18 (13.4%) | 11 (3.7%) | 4 (4.0%) | 1 (3.0%) |
| 2–5 | 42 (31.6%) | 60 (44.8%) | 115 (39.1%) | 16 (16.0%) | 9 (27.3%) |
| 6–10 | 18 (13.5%) | 19 (14.2%) | 64 (21.8%) | 15 (15.0%) | 1 (3.0%) |
| 11–15 | 16 (12.0%) | 8 (6.0%) | 30 (10.2%) | 8 (8.0%) | 1 (3.0%) |
| 16–24 | 11 (8.3%) | 6 (4.5%) | 25 (8.5%) | 4 (4.0%) | 4 (12.1%) |
| 25 or more | 18 (13.5%) | 4 (3.0%) | 44 (15.0%) | 43 (43.0%) | 15 (45.5%) |
| Missing | 17 (12.8%) | 13 (9.7%) | 2 (0.7%) | 0 (0.0%) | 0 (0.0%) |
| Year baseline | |||||
| sample collected: | 2011 | 2011 | 2018 | 2017 | 2017 |
| Median (range) | (2009–2013) | (2009–2013) | (2017–2018) | (2017–2018) | (2017–2018) |
a
The HOTSPOT control group included 33 convenience controls and 101 spouses/partners of HPV-positive OPC patients, all of whom had a head and neck examination ruling out cancer.
b
HIV-positive participants had a median current CD4 cell count of 458.5 (IQR = 273–660.5).