Table 2).

Summary of SILCS-Hotspots sites identified in the Androgen Receptor including the top 2 ranked sites and those adjacent to the orthosteric (DHT) and allosteric (FLA) binding sites.

Site	Hotspot Rank	Minimum Distance to Ligand	Mean LGFE	# of Fragments	Most favorable LGFE	Most favorable LE
	1	NA	−3.65	11	−4.8	−0.77
	2	NA	−3.60	3	−3.9	−0.49
DHT	26	0.8	−2.82	25	−4.3	−0.53
	57	3.6	−2.48	2	−2.9	−0.34
FLA	3	0.9	−3.47	47	−6.2	−0.86
	17	1.2	−2.91	16	−4.1	−0.60
	34	1.6	−2.71	55	−5.1	−0.59

Distances are in Å and energies in kcal/mol. Hotspot rank is based on the Mean LGFE. LE is the ligand efficiency based on the LGFE/# of non-hydrogen atoms. NA indicates that the top 2 ranked sites are not adjacent to the ligands.