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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2019 Aug 23;1861(12):183051. doi: 10.1016/j.bbamem.2019.183051

Figure 4. Conformation of Leu2.46 affects the suggested pathway of Na+ escape to the cytoplasm in the muscarinic acetylcholine receptor M2.

Figure 4.

A. Sodium-binding cavity in the M2 receptor in the antagonist-bound inactive state (PDB 3UON, [12]). B. A minor rotameric transition of Leu2.46 alone is enough to open the connection between two inner cavities, allowing the Na+ ion passage through the layer of conserved hydrophobic residues (see also Fig. S4). The dashed circles mark the Van der Waals radii as calculated by the PyMol v 1.7 software [44].