Table 2.
Initial parameters of the model
| Parameter | Value | Descriptiona |
|---|---|---|
| M | 103 M−1 | Association constant of the sodium ion (initial value) |
| N | 107 M−1 | Association constant of the agonist (initial value) |
| L | 1 | Receptor activation constant |
| α | 10−3 | Intrinsic efficacy of sodium: ratio of affinity of sodium for R* and R |
| β | 103 | Intrinsic efficacy of the agonist: ratio of affinity of the agonist for R* and R |
| γ | 10−2 | Binding cooperativity between the sodium ion and the agonist: ratio of affinity of A for R-Na and R, or of Na for R-A and R |
| δ | 102 | Activation cooperativity between the sodium ion and the agonist: ratio of affinity of A for R*-Na and R-Na, or of Na for R*-A and R-A |
| [Na+]out | 140 mM | [Na+] in the extracellular medium |
| [Na+]in | 10 mM | [Na+] in the cell cytoplasm |
a
The designations of parameters are taken from ref. [51].