Fig. 3.

BRD4 increases PC cell growth in vivo. a–c Subcutaneous tumor transplantation test showed that, compared with PANC-1/BRD4-nc, PANC-1/BRD4-sh1 and PANC-1/BRD4-sh2 groups had slower growth rate (a) and tumor weight (b, c). d Representative immunohistochemical images for BRD4, ki67 and cleaved Caspase3 expression. In comparisons with PANC-1/BRD4-nc, both PANC-1/BRD4-sh1 and PANC-1/BRD4-sh2 groups had lower BRD4 and ki67 expression. However, cleaved Caspase 3 was negatively expressed in all groups. Scale bar, 50 μm. The asterisk indicates that p is less than 0.05