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. 2020 Feb 18;20:55. doi: 10.1186/s12935-020-1135-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CAV-2 is a downstream target of BRD4. a RNA sequence was employed to identify the downstream target of BRD4. The results showed that there were 27 differentially expressed gene, 12 upregulations and 15 downregulation. Among them, the downregulation of CAV-2 was the second most. b, c The CAV-2 mRNA (b) and protein (c) level in both BRD4-si1 and BRD4-si2 group was down-regulated. d, e Compared to BRD4-ctrl group, the CAV-2 mRNA (d) and protein (e) in BRD4-over group was up-regulated. f Sulforhodamine B assays showed that both CAV-2-si1 and CAV-2-si2 group significantly suppressed cell proliferation compared to CAV-2-nc group. g Sulforhodamine B assays showed that CAV-2-over group significantly promoted cell proliferation compared to BRD4-ctrl group. h Migration assay showed that both CAV-2-si1 and CAV-2-si2 group did not significantly suppressed cell migration and invasion compared to CAV-2-nc group. i Migration assay showed that BRD4-over group did not significantly increased cell migration and invasion compared to BRD4-ctrl group. The asterisk indicates that p is less than 0.05