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. 2020 Feb 18;20:55. doi: 10.1186/s12935-020-1135-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — BRD4 regulates CAV-2 transcriptional activity. a ChIP results showed that BRD4 can directly bind to the promoter region (0 ~ − 500 bp, − 500 ~ − 1000 bp and − 1000 ~ − 1500 bp) of CAV-2. b Compared to BRD4-nc group, BRD4-si1 exhibited a reduced BRD4 recruitment to CAV-2 promoter. c Luciferase reporter experiment suggested that BRD4 had transcriptional activity at the − 1500 ~ 0 bp promoter region of CAV-2. After interfering with BRD4 expression, the transcriptional activation of CAV-2 could be inhibited. The asterisk indicates that p is less than 0.05