Table 3.
Summary of univariate and multivariate Cox regression analysis of overall survival
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| BRD4 | ||||||
| Low | 1 | 1 | ||||
| High | 3.321 | 1.592–6.930 | 0.001* | 2.244 | 1.009–4.990 | 0.047* |
| CAV-2 | ||||||
| Low | 1 | 1 | ||||
| High | 3.666 | 1.881–7.143 | < 0.001* | 2.370 | 1.108–5.071 | 0.026* |
| Age (years) | ||||||
| ≤ 60 | 1 | |||||
| > 60 | 0.765 | 0.415–1.409 | 0.390 | |||
| Gender | ||||||
| Male | 1 | |||||
| Female | 1.116 | 0.600–2.076 | 0.728 | |||
| Clinical stage | ||||||
| Early stages (≤ I) | 1 | 1 | ||||
| Advanced stages (> I) | 4.059 | 1.255–13.123 | 0.019* | 2.120 | 0.560–8.025 | 0.269 |
| Invasion depth | ||||||
| T1 + T2 | 1 | |||||
| T3 + T4 | 1.937 | 0.864–4.342 | 0.109 | |||
| Lymph nodes metastasis | ||||||
| N0 (negative) | 1 | |||||
| N1 (positive) | 1.264 | 0.699–2.284 | 0.439 | |||
| Distant metastasis | ||||||
| M0 (Absent) | 1 | |||||
| M1 (Present) | 0.597 | 0.144–2.468 | 0.476 | |||
| Tumor differentiation | ||||||
| Well, moderate | 1 | 1 | ||||
| Poor | 1.963 | 1.084–3.553 | 0.026* | 1.798 | 0.916–3.530 | 0.088 |
| Tumor location | ||||||
| Head, neck | 1 | |||||
| Body, tail | 1.541 | 0.854–2.779 | 0.151 | |||
| Nervous invasion | ||||||
| Negative | 1 | 1 | ||||
| Positive | 2.018 | 1.020–3.993 | 0.044* | 0.995 | 0.470–2.106 | 0.990 |
| Vessel invasion | ||||||
| Negative | 1 | 1 | ||||
| Positive | 4.107 | 1.978–8.528 | < 0.001* | 4.100 | 1.715–9.804 | 0.002* |
Asterisk represents the significant difference