Table 2.
Analysis predictors of progression-free survival and overall survival in patients with HCC
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Progression-free survival | ||||||
| Sex (male vs female) | 1.27 | 0.73–2.37 | 0.507 | |||
| Age, y (> 50 vs ≤ 50) | 1.16 | 0.78–1.72 | 0.446 | |||
| Drinking (present vs absent) | 0.95 | 0.64–1.42 | 0.832 | |||
| HBsAg (positive vs negative) | 0.82 | 0.49–1.37 | 0.469 | |||
| Tumor number (multiple vs single) | 1.78 | 1.16–2.80 | 0.007 | |||
| Tumor size, cm (> 5 vs ≤ 5) | 2.61 | 1.73–3.37 | < 0.001 | 1.75 | 1.23–2.67 | 0.003 |
| Liver cirrhosis (present vs absent) | 1.33 | 0.65–2.75 | 0.429 | |||
| MVI (MVI vs non-MVI) | 2.58 | 1.86–3.58 | < 0.001 | 1.91 | 1.35–2.71 | < 0.001 |
| AFP, ng/ml (> 20 vs ≤ 20) | 1.59 | 1.12–2.26 | 0.010 | |||
| GLR (> 56 vs ≤ 56) | 2.36 | 1.53–3.08 | < 0.001 | 1.56 | 1.18–2.36 | 0.017 |
| Overall survival | ||||||
| Sex (male vs female) | 1.13 | 0.62–2.09 | 0.716 | |||
| Age, y (> 50 vs ≤ 50) | 1.08 | 0.73–1.61 | 0.671 | |||
| Drinking (present vs absent) | 0.83 | 0.56–1.24 | 0.371 | |||
| HBsAg (positive vs negative) | 0.72 | 0.43–1.21 | 0.224 | |||
| Tumor number (multiple vs single) | 1.83 | 1.20–2.66 | 0.004 | |||
| Tumor size, cm (> 5 vs ≤ 5) | 2.87 | 2.10–3.76 | < 0.001 | 2.11 | 1.48–3.07 | < 0.001 |
| Liver cirrhosis (present vs absent) | 1.13 | 0.55–2.33 | 0.732 | |||
| MVI (MVI vs non-MVI) | 2.83 | 2.05–3.61 | < 0.001 | 2.00 | 1.41–2.84 | < 0.001 |
| AFP, ng/ml (> 20 vs ≤ 20) | 1.64 | 1.15–2.33 | 0.006 | |||
| GLR (> 56 vs ≤ 56) | 2.47 | 1.80–3.40 | < 0.001 | 1.63 | 1.28–2.31 | 0.006 |
HR hazard ratio, CI confidence interval, HBsAg hepatitis B surface antigen, MVI microvascular invasion, AFP alpha-fetoprotein, GLR GGT to lymphocyte ratio